Welcome to the Grundner lab
The Grundner lab is at the Seattle Children’s Research Institute (Center for Global Infectious Disease Research) in the South Lake Union neighborhood of Seattle. We are also affiliated with the Department of Global Health at the University of Washington, Seattle.
Mycobacterium tuberculosis (Mtb) remains the most deadly bacterial pathogen, and rampant drug resistance is requiring renewed efforts to develop new and better therapies. Towards this end, the Grundner lab seeks to understand the biology of Mtb phosphosignaling and the biochemical basis of persistence and latency. We use microbiology, chemical biology, biochemistry, and structural biology approaches to answer the following questions:
- How is the Mtb phosphosignaling system wired and how does phosphosignaling facilitate bacterial adaptation? Read more
- How can we accelerate functional genomics to discover functions of the Mtb proteins with unknown function? Read more
- What is the biochemical basis of non-replication in Mtb that is responsible for persistence and latency? How can we specifically target these populations? Read more