Grundner Lab Publications

Click the “Free Article” or “PMC Full Text” links for open access to our publications (if allowed by the publisher).

Grundner C. To fight tuberculosis, fund basic research. PLoS Biol. 2018;16(9):e3000037. | Pubmed | Full Article |

Abendroth J, Frando A, Phan IQ, Staker BL, Myler PJ, Edwards TE, Grundner C. Mycobacterium tuberculosis Rv3651 is a triple sensor-domain protein. Protein Sci. 2018 Feb;27(2):568-572. doi: 10.1002/pro.3343. Epub 2017 Dec 5. PubMed PMID: 29119630; PubMed Central PMCID: PMC5775179. | Pubmed | Article (Paywall) |

Ortega C, Frando A, Webb-Robertson BJ, Anderson LN, Fleck ND, Flannery EL, Fishbaugher M, Murphree TA, Hansen JR, Smith RD, Kappe SH, Wright A, Grundner C. A global survey of ATPase activity in Plasmodium falciparum asexual blood stages and gametocytes. Mol Cell Proteomics. 2017 Oct 27. pii: mcp.RA117.000088. doi:10.1074/mcp.RA117.000088. | Pubmed | Free Article |

Ortega C, Anderson LN, Frando A, Sadler NC, Brown RW, Smith RD, Wright AT, Grundner C. Systematic Survey of Serine Hydrolase Activity in Mycobacterium tuberculosis Defines Changes Associated with Persistence. Cell Chem Biol. 2016 Feb 18;23(2):290-8. doi: 10.1016/j.chembiol.2016.01.003. Epub 2016 Feb 4.|  Pubmed | Free Article |

3: Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD. Crystal structures of Mycobacterial MeaB and MMAA-like GTPases. J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi:10.1007/s10969-015-9197-2. Epub 2015 Apr 2. | Pubmed | Article (paywall) | PMC Full Text |

Sherman DR, Grundner C. Agents of change – concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling. Mol Microbiol. 2014 Oct;94(2):231-41. doi: 10.1111/mmi.12747. Epub 2014 Aug 25. | Pubmed | Free Article |

Kusebauch U, Ortega C, Ollodart A, Rogers RS, Sherman DR, Moritz RL, Grundner C. Mycobacterium tuberculosis supports protein tyrosine phosphorylation. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9265-70. doi: 10.1073/pnas.1323894111. Epub 2014 Jun 9. | Pubmed | Free Article |

Abendroth J, Ollodart A, Andrews ES, Myler PJ, Staker BL, Edwards TE, Arcus VL, Grundner C. Mycobacterium tuberculosis Rv2179c protein establishes a new exoribonuclease family with broad phylogenetic distribution. J Biol Chem. 2014 Jan 24;289(4):2139-47. | Pubmed | Free Article |

Ortega C, Liao R, Anderson LN, Rustad T, Ollodart AR, Wright AT, Sherman DR, Grundner C. Mycobacterium tuberculosis Ser/Thr protein kinase B mediates an oxygen-dependent replication switch. PLoS Biol. 2014 Jan;12(1):e1001746. | Pubmed | Free Article |

Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi CR. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5069-77. doi: 10.1073/pnas.1321205110. Epub 2013 Dec 5. | Pubmed | Free Article |

Ansong C, Ortega C, Payne SH, Haft DH, Chauvignè-Hines LM, Lewis MP, Ollodart AR, Purvine SO, Shukla AK, Fortuin S, Smith RD, Adkins JN, Grundner C, Wright AT. Identification of widespread adenosine nucleotide binding in Mycobacterium tuberculosis. Chem Biol. 2013 Jan 24;20(1):123-33. | Pubmed | Free Article |

Edwards TE, Liao R, Phan I, Myler PJ, Grundner C. Mycobacterium thermoresistibile as a source of thermostable orthologs of Mycobacterium Tuberculosis proteins. Protein Sci. 2012 Jul;21(7):1093-6. doi: 10.1002/pro.2084. Epub 2012 May 24. | Pubmed | Free Article |

Vega C, Chou S, Engel K, Harrell ME, Rajagopal L, Grundner C. Structure and substrate recognition of the Staphylococcus aureus protein tyrosine phosphatase PtpA. J Mol Biol. 2011 Oct 14;413(1):24-31. doi: 10.1016/j.jmb.2011.08.015. Epub 2011 Aug 17. | Pubmed | Free Article |

Rawls KA, Grundner C, Ellman JA. Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Org Biomol Chem. 2010 Sep 21;8(18):4066-70. doi: 10.1039/c0ob00182a. Epub 2010 Jul 19. | Pubmed | Article (paywall) | PMC Full Text |

Chou S, Jensen BC, Parsons M, Alber T, Grundner C. The Trypanosoma brucei life cycle switch TbPTP1 is structurally conserved and dephosphorylates the nucleolar protein NOPP44/46. J Biol Chem. 2010 Jul 16;285(29):22075-81. doi: 10.1074/jbc.M110.108860. Epub 2010 May 5. | Pubmed | Free Article |

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